Vibration analysis of the beam structure under the moving mass

Analytical solution of vibration of simply supported beam under the action of centralized moving mass and two numerical methods using life and death element method and displacement contact method are analyzed in this paper. The results show that vertical acceleration resulted from speed and centrifugal acceleration resulted from load moving must be taken into consideration for large quality and high speed. The characteristics and applicable situations of the two numerical methods are also studied to provide a basis for analyzing and considering structural dynamic problems of moving load mass

Synthesis of CoSe2-SnSe2 nanocube-coated nitrogen-doped carbon (NC) as anode for lithium and sodium ion batteries

CoSe2-SnSe2/NC nanocubes (CSNC@NC) coated by nitrogen-doped carbon (NC) were synthesized successfully by an ordinary pyrazole polymerization and carbonization process. In comparison with bare CSNC, the CSNC@NC composite exhibited good structural stability and improved electrical conductivity when used as anode. The CSNC@NC electrode showed a stable Li storage capacity (730.41 mAh g−1 over 100 cycles at 0.2 A g−1) and excellent rate performance (402.10 mAh g−1 at 2 A g−1). For Na storage, the discharge capacity could be maintained 279.3 mAh g−1 over 100 cycles at 0.2 A g−1; the lower capacity than that for Li storage maybe caused by the larger size of Na+ ions. The excellent cycling stability for both Li and Na storage cycle ability may be attributed to the carbon layer, which could tolerated the volume fluctuations and ensured the structural integrity of the CSNC during the charge/discharge process; Moreover, the improved electrical conductivity accelerated the diffusion rate of both Li+ and Na+, which is conducive to the electrochemical reactions in their respective batteries. This unique structure and preeminent electrochemical performance of CSNC@NC show that CSNC@NC is a promising anode material for high-efficiency Li ion and Na ion batteries

Chidamide and Decitabine in Combination with a HAG Priming Regimen for Acute Myeloid Leukemia with TP53 Mutation

We analyzed the treatment effects of chidamide and decitabine in combination with a HAG (homoharringtonine, cytarabine, G-CSF) priming regimen (CDHAG) in acute myeloid leukemia (AML) patients with TP53 mutation. Seven TP53 mutated AML patients were treated with CDHAG. The treatment effects were assessed using hemogram detection and bone marrow aspirate. The possible side effects were evaluated based on both hematological and non-hematological toxicity. Four of the seven patients were classified as having achieved complete remission after CDHAG treatment; one patient was considered to have achieved partial remission, and the remaining two patients were considered in non-remission. The overall response rate (ORR) to CDHAG was 71.4%. Regarding the side effects, the hematological toxicity level of the seven patients ranged from level III to level IV, and infections that occurred at lung, blood, and skin were recorded. Nausea, vomiting, liver injury, and kidney injury were also detected. However, all side effects were attenuated by proper management. The CDHAG regimen clearly improved the ORR (71.4%) of TP53-mutated AML patients, with no severe side effects

Free vibration of thick annular sector plate on Pasternak foundation with general boundary conditions

In this paper, the free vibration of the thick annular sector plate on Pasternak foundation with general boundary conditions is presented by using the three-dimensional elasticity theory and the improved Fourier series method. The displacements of the thick annular sector plate are expanded to be the three-dimensional (3-D) Fourier cosine series supplemented with several auxiliary functions to eliminate all the relevant discontinuities of the displacements and their derivatives at the edges with general boundary conditions. This method can be universally applied to any kinds of classical boundaries, elastic boundaries and the combinations of both boundaries without any special change in the solution procedure. The excellent accuracy and reliability of the current solutions are demonstrated by numerical examples and comparison of the present results with those available in the literature. Furthermore, numerous new results for thick annular sector plates on Pasternak foundation with general elastic restrains are presented. In addition, comprehensive studies on the effects of the elastic restraint parameters, geometric parameters and elastic foundation coefficients are also reported

The strengthening effect of inter-layer cold working and post-deposition heat treatment on the additively manufactured Al-6.3Cu alloy

Wire + Arc Additive Manufacture (WAAM) attracts great interest from the aerospace industry for producing components with aluminum alloys, particularly Al-Cu alloy of the 2000 series such as 2219 alloy. However the application is restricted by the low strength properties of the as-deposited WAAM metal. In this study two strengthening methods were investigated - inter-layer cold working and post-deposition heat treatment. Straight wall samples were prepared with 2319 aluminum alloy wire. Inter-layer rolling with loads of 15 kN, 30 kN and 45 kN were employed during deposition. The ultimate tensile strength (UTS) and yield strength (YS) of the inter-layer rolled alloy with 45 kN load can achieve 314. MPa and 244. MPa respectively. The influence of post-deposition T6 heat treatment was investigated on the WAAM alloy with or without rolling. Compared with inter-layer rolling, post-deposition heat treatment can provide much greater enhancement of the strength. After T6 treatment, the UTS and YS of both of the as-deposited and 45 kN rolled alloys exceeded 450. MPa and 305. MPa respectively, which are higher than the properties of the wrought 2219-T6 alloy. The strengthening mechanisms of this additively manufactured Al-6.3Cu alloy were investigated through microstructure analysis

A unified formulation for vibration analysis of open cylindrical shells coupled with annular sector plates under general boundary and coupling conditions

A unified formulation for vibration analysis of coupled open cylindrical shell and annular sector plate system with general boundary and coupling conditions is presented in this study by using a modified Fourier-Ritz method. Under the framework, each of the displacements of the open cylindrical shell and the annular sector plate, regardless of boundary and coupling conditions, is expanded as a two-dimensional (2-D) Fourier cosine series supplemented with closed-form auxiliary functions introduced to remove the potential discontinuities at the junction and accelerate the convergence of the series expansion. Since the displacement fields are constructed adequately smooth throughout the entire solution domain, an exact solution is obtained based on the Rayleigh-Ritz procedure by using the energy functions of the coupled system. The arbitrary coupling position and included angle of the open cylindrical shell-annular sector plate structure considered in the theoretical formulation make the present method more general. The convergence and accuracy of the present method are tested and validated by a number of numerical examples for open cylindrical shell-annular sector plate structure with various boundary restraints and general elastic coupling conditions. Some new results are presented to provide useful information for future researchers

Isolation and characterization of a novel alphanodavirus

<p>Abstract</p> <p>Background</p> <p><it>Nodaviridae </it>is a family of non-enveloped isometric viruses with bipartite positive-sense RNA genomes. The <it>Nodaviridae </it>family consists of two genera: alpha- and beta-nodavirus. Alphanodaviruses usually infect insect cells. Some commercially available insect cell lines have been latently infected by Alphanodaviruses.</p> <p>Results</p> <p>A non-enveloped small virus of approximately 30 nm in diameter was discovered co-existing with a recombinant <it>Helicoverpa armigera </it>single nucleopolyhedrovirus (<it>Hear</it>NPV) in Hz-AM1 cells. Genome sequencing and phylogenetic assays indicate that this novel virus belongs to the genus of alphanodavirus in the family <it>Nodaviridae </it>and was designated HzNV. HzNV possesses a RNA genome that contains two segments. RNA1 is 3038 nt long and encodes a 110 kDa viral protein termed protein A. The 1404 nt long RNA2 encodes a 44 kDa protein, which exhibits a high homology with coat protein precursors of other alphanodaviruses. HzNV virions were located in the cytoplasm, in association with cytoplasmic membrane structures. The host susceptibility test demonstrated that HzNV was able to infect various cell lines ranging from insect cells to mammalian cells. However, only Hz-AM1 appeared to be fully permissive for HzNV, as the mature viral coat protein essential for HzNV particle formation was limited to Hz-AM1 cells.</p> <p>Conclusion</p> <p>A novel alphanodavirus, which is 30 nm in diameter and with a limited host range, was discovered in Hz-AM1 cells.</p

Bis(6′-carb­oxy-2,2′-bipyridine-6-carboxyl­ato-κ3 N,N′,O 6)nickel(II) tetra­hydrate

In the title compound, [Ni(C12H7N2O4)2]·4H2O, the Ni atom is located at the centre of a distorted octa­hedron, formed by four N atoms and two O atoms from the same two tridentating chelated 6-carb­oxy-2,2′-bipyridine-6′-carboxyl­ate (L) ligands. Face-to-face π-stacking inter­actions between inversion-related pyridine rings with centroid–centroid distances of 3.548 (3) and 3.662 (3) Å (perpendicular distances between the respective rings are 3.314 and 3.438 Å) are found. Inter­molecular O—H⋯O hydrogen bonds between water mol­ecules and L ligands form R 5 3(10), R 6 5(14) and R 5 5(12) rings and also a centrosymmetric cage-like unit of water mol­ecules, which link eight adjacent NiII centers, forming a three-dimensional framework